Purified NA/LE Rat Anti-Mouse CD49d

產品名稱:Purified NA/LE 大鼠抗小鼠 CD49d 抗體；Purified NA/LE Rat Anti-Mouse CD49d

中文名稱:Purified NA/LE 大鼠抗小鼠 CD49d 抗體

英文名稱:Purified NA/LE Rat Anti-Mouse CD49d

Purified NA/LE Rat Anti-Mouse CD49d 產品介紹：

Material Number: 553153
Alternate Name: Integrin α4 chain
Size: 0.5 mg
Concentration: 1.0 mg/ml
Clone: R1-2
Immunogen: AKR/Cum mouse spontaneous T lymphoma line TK1
Isotype: Rat (F344) IgG2b, κ
Reactivity: QC Testing: Mouse
Storage Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 
0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of 
protein as determined by the LAL assay.

The R1-2 antibody reacts with the integrin α4 chain (CD49d), which is expressed as a heterdimer with either of two β, β1 or β7 (also known as 
βp). The α4β1 integrin (VLA-4, CD49d/CD29) is expressed on most peripheral lymphocytes, thymocytes, and monocytes; while the α4β7 
integrin (LPAM-1) is expressed on peripheral lymphocytes, but on only a small subset of thymocytes. These integrins mediate a variety of 
cell-cell and cell-matrix interactions, recognizing the ligands VCAM-1 (CD106) and fibronectin. There is evidence that levels of VLA-4 
expression regulate the transendothelial migration of T lymphocytes into inflamed tissues. Integrin α4β7 also preferentially binds to the 
mucosal vascular addressin, MAdCAM-1. The R1-2 antibody blocks some α4 integrin-mediated binding functions. In combination with mAb 
9C10 (MFR4.B) (Cat. No. 553313), binding of VLA-4 expressing cells to VCAM-1 can be almost completely inhibited. 

Purified NA/LE Rat Anti-Mouse CD49d Preparation and Storage：

Store undiluted at 4°C.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
This preparation contains no preservatives, thus it should be handled under aseptic conditions.