Purified Rat Anti-Mouse CD31

產品名稱:Purified 大鼠抗小鼠 CD31 抗體；Purified Rat Anti-Mouse CD31

中文名稱:Purified 大鼠抗小鼠 CD31 抗體

英文名稱:Purified Rat Anti-Mouse CD31

Purified Rat Anti-Mouse CD31 產品介紹：

Material Number: 553370
Alternate Name: PECAM-1
Size: 0.5 mg
Concentration: 0.5 mg/ml
Clone: MEC 13.3
Immunogen: 129/Sv mouse-derived endothelioma cell line tEnd.1
Isotype: Rat (LEW) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide



Purified Rat Anti-Mouse CD31 Description：

The MEC13.3 antibody reacts with CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1). CD31 is a 130 kDa 
integral membrane protein, a member of the immunoglobulin superfamily, that mediates cell-to-cell adhesion. CD31 is expressed 
constitutively on the surface of ***** and embryonic endothelial cells and is weakly expressed on many peripheral leukocytes and platelets. It 
has also been detected on bone marrow-derived hematopoietic stem cells and embryonic stem cells. CD31 is involved in the transendothelial 
emigration of neutrophils, and neutrophil PECAM-1 appears to be down-regulated after extravasation into inflamed tissues. Multiple 
alternatively spliced isoforms are detected during early post-implantation embryonic development; this alternative splicing is involved in the 
regulation of ligand specificity. CD38 and vitronectin receptor (αvβ3 integrin, CD51/CD61) are proposed to be ligands for CD31. 
CD31-mediated endothelial cell-cell interactions are involved in angiogenesis. The MEC13.3 mAb inhibits a variety of in vitro and in vivo 
functions mediated by CD31. 

Purified Rat Anti-Mouse CD31 Preparation and Storage：

Store undiluted at 4°C.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography